A leukocyte integrin binding peptide from intercellular adhesion molecule-2 stimulates T cell adhesion and natural killer cell activity.

@article{Li1993ALI,
  title={A leukocyte integrin binding peptide from intercellular adhesion molecule-2 stimulates T cell adhesion and natural killer cell activity.},
  author={Rui Li and Pekka Nortamo and Carmela Kantor and Petri T. Kovanen and Tuomo Timonen and Carl G Gahmberg},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 29},
  pages={21474-7}
}
Adhesion is of pivotal importance for a number of leukocyte functions. Little is known about the binding between leukocyte integrins and the intercellular adhesion molecules (ICAMs). Normally integrins are nonadhesive, and require a stimulus to become active. We have now identified a peptide from ICAM-2, which binds to leukocyte integrins and activates adhesion. Furthermore, the peptide strongly increased the binding and cytotoxicity of natural killer cells. These findings show that adhesion… CONTINUE READING

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