A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes.

@article{Valencik2002ALP,
  title={A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes.},
  author={Maria L. Valencik and Rebecca S. Keller and Joseph C. Loftus and John Alan McDonald},
  journal={Journal of cardiac failure},
  year={2002},
  volume={8 4},
  pages={262-72}
}
BACKGROUND Integrins are heterodimeric receptors that couple the extracellular matrix to intracellular signaling pathways and the cyoskeleton. Integrins are strain transducers and candidates for modulators or effectors of cardiac hypertrophy. METHODS To begin to probe this function, we have transgenically expressed a chimeric protein that alters integrin… CONTINUE READING