A less costly regimen of alglucerase to treat Gaucher's disease.

  title={A less costly regimen of alglucerase to treat Gaucher's disease.},
  author={Max Figueroa and Barry E Rosenbloom and Alan C. Kay and Paul Garver and Damon Thurston and James A. Koziol and Terri Gelbart and Ernest Beutler},
  journal={The New England journal of medicine},
  volume={327 23},
BACKGROUND Alglucerase (Ceredase) provides effective enzyme-replacement treatment for patients with Gaucher's disease, but at the usually recommended dose of 60 U per kilogram of body weight every two weeks (130 U per kilogram per month), it costs $382,200 per year for a 70-kg patient. Theoretical considerations suggest that more frequent administration would be more efficient. METHODS Fourteen patients with type 1 Gaucher's disease that was moderately severe to severe were given 30 U of… CONTINUE READING

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