A lentiviral cDNA library employing lambda recombination used to clone an inhibitor of human immunodeficiency virus type 1-induced cell death.

@article{Kawano2004ALC,
  title={A lentiviral cDNA library employing lambda recombination used to clone an inhibitor of human immunodeficiency virus type 1-induced cell death.},
  author={Yuji Kawano and Takeshi Yoshida and Kuniko Hieda and Jun Aoki and Hiroyuki Miyoshi and Yoshio Koyanagi},
  journal={Journal of virology},
  year={2004},
  volume={78 20},
  pages={11352-9}
}
Expression cloning technology of cDNAs is a suitable tool for identifying novel functional properties of genes. Here, we generated a lentiviral cDNA library-expressing system for human T cells based on a site-specific recombination system of phage lambda for transferring cDNA libraries with a minimum loss of its complexity. The library-transduced CD4(+) T cells were challenged with wild-type human immunodeficiency virus type 1 (HIV-1), and the cells that acquired resistance to HIV-1-induced… CONTINUE READING
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