A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder.

@article{Benedetti2008ALP,
  title={A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder.},
  author={Francesco Benedetti and Sara Dallaspezia and Cristina Colombo and Adele Pirovano and Elena Marino and Enrico Smeraldi},
  journal={Neuroscience letters},
  year={2008},
  volume={445 2},
  pages={184-7}
}
Age at onset of bipolar disorder might represent the penetrance of the system for specific genetic liability involved in the genesis of the illness. Genetic factors influencing age at onset have been shown to play a role in shaping core characteristics of the illness, such as severity and pattern of recurrence. Genetic variants of genes regulating the circadian clock could contribute to define endophenotypes of bipolar disorder, and have been associated with clinical features of the disease… CONTINUE READING