A leech homolog of twist: evidence for its inheritance as a maternal mRNA.

  title={A leech homolog of twist: evidence for its inheritance as a maternal mRNA.},
  author={Julio G. Soto and Brad H. Nelson and David A. Weisblat},
  volume={199 1-2},
In the development of leeches such as Helobdella robusta, mesodermal and ectodermal fates segregate to cells DM and DNOPQ, respectively, at fourth cleavage. As one step in identifying genes that may act in mesoderm determination, we have cloned the H. robusta homolog to the Drosophila gene twist. This homolog, designated Hro-twi, exhibits high (> 90%) amino acid identity with other twist-class genes within its basic-helix loop-helix (b-HLH) DNA binding motif and dimerization domain. Like twist… CONTINUE READING
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