A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast.

@article{Oelkers2000ALC,
  title={A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast.},
  author={Peter Oelkers and Arthur H. Tinkelenberg and Naz Erdeniz and Debra A Cromley and Jeffrey T. Billheimer and Stephen L. Sturley},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 21},
  pages={15609-12}
}
The terminal step in triglyceride biosynthesis is the esterification of diacylglycerol. To study this reaction in the model eukaryote, Saccharomyces cerevisiae, we investigated five candidate genes with sequence conservation to mammalian acyltransferases. Four of these genes are similar to the recently identified acyl-CoA diacylglycerol acyltransferase and, when deleted, resulted in little or no decrease in triglyceride synthesis as measured by incorporation of radiolabeled oleate or glycerol… CONTINUE READING

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