A lattice model of ternary mixtures of lipids and cholesterol with tunable domain sizes.

  title={A lattice model of ternary mixtures of lipids and cholesterol with tunable domain sizes.},
  author={Tanmoy Sarkar and Oded Farago},
  journal={Soft matter},
Much of our understanding of the physical properties of raft domains in biological membranes, and some insight into the mechanisms underlying their formation stem from atomistic simulations of simple model systems, especially ternary mixtures consisting of saturated and unsaturated lipids, and cholesterol (Chol). To explore the properties of such systems at large spatial scales, we here present a simple ternary mixture lattice model, involving a small number of nearest neighbor interaction… 

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  • 2007
Observations on three-component bilayer mixtures containing cholesterol show rich phase behavior, including several regions of two-phase coexistence and one region of three- phase coexistence, suggesting that if the underlying interaction energies between lipids and proteins can be determined, then it might be possible to model the distributions of lipid and proteins in a bilayer membrane, even in complex mixtures.