A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

  title={A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse},
  author={Jens P. Magnusson and Christian G{\"o}ritz and Jemal Tatarishvili and David Oliveira Dias and Emma M. K. Smith and Olle Lindvall and Zaal Kokaia and Jonas Fris{\'e}n},
Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced in pathological situations. We report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. Blocking Notch signaling triggers astrocytes in the striatum and the medial cortex to enter a neurogenic program… CONTINUE READING
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