A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

@article{Magnusson2014ALN,
  title={A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse},
  author={Jens P. Magnusson and Christian G{\"o}ritz and Jemal Tatarishvili and David Oliveira Dias and Emma M. K. Smith and Olle Lindvall and Zaal Kokaia and Jonas Fris{\'e}n},
  journal={Science},
  year={2014},
  volume={346},
  pages={237-241}
}
Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced in pathological situations. We report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. Blocking Notch signaling triggers astrocytes in the striatum and the medial cortex to enter a neurogenic program… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 24 references

Cell

A Ernst
Cell • 2014

Demogr. Res

B K Fosdick, A E Raftery
Demogr. Res • 2014

Neuron

I Imayoshi, R Kageyama
Neuron • 2014

Stat. Sci

A E Raftery, L Alkema, P Gerland
Stat. Sci • 2014

Cell Stem Cell

S Sirko
Cell Stem Cell • 2013

Demographic Components of Future Population Growth (Technical Paper no

K Andreev, V Kantorová, J Bongaarts
Population Division, Department of Economic and Social Affairs, United Nations • 2013

Nat. Cell Biol

W Niu
Nat. Cell Biol • 2013

Popul. Dev. Rev

J Bongaarts, J Casterline
Popul. Dev. Rev • 2013

Population Facts No

December 2013 -Explaining Differences in the Projected Populations Between REFERENCES AND NOTES • 2013

UNAIDS Report on the Global AIDS Epidemic

Unaids, Global Report
UNAIDS Report on the Global AIDS Epidemic • 2013

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