A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network.

Abstract

Reprogramming of somatic cells to a pluripotent state via expression of Oct4, Klf4, Myc, and Sox2 is a multistep process involving phased changes in gene expression. Here, we focus on the later stages of reprogramming, termed maturation and stabilization. We show that the stabilization phase and the acquisition of pluripotency are dependent on the removal… (More)
DOI: 10.1016/j.stem.2012.11.008

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