A late phase of LTD in cultured cerebellar Purkinje cells requires persistent dynamin-mediated endocytosis.

@article{Linden2012ALP,
  title={A late phase of LTD in cultured cerebellar Purkinje cells requires persistent dynamin-mediated endocytosis.},
  author={David J Linden},
  journal={Journal of neurophysiology},
  year={2012},
  volume={107 1},
  pages={
          448-54
        }
}
Long-term synaptic depression (LTD) of cerebellar parallel fiber-Purkinje cell synapses is a form of use-dependent synaptic plasticity that may be studied in cell culture. One form of LTD is induced postsynaptically through an mGlu1/Ca influx/protein kinase Cα (PKCα) cascade, and its initial expression requires phosphorylation of ser-880 in the COOH-terminal PDZ-ligand region of GluA2 and consequent binding of PICK1. This triggers postsynaptic clathrin/dynamin-mediated endocytosis of GluA2… CONTINUE READING

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