A large-scale study of differential gene expression in monocyte-derived macrophages infected with several strains of Mycobacterium avium subspecies paratuberculosis.

@article{Kabara2010ALS,
  title={A large-scale study of differential gene expression in monocyte-derived macrophages infected with several strains of Mycobacterium avium subspecies paratuberculosis.},
  author={Edward A Kabara and Christopher C Kloss and Melind Wilson and Robert J. Tempelman and Srinand Sreevatsan and Harish K Janagama and Paul M. Coussens},
  journal={Briefings in functional genomics},
  year={2010},
  volume={9 3},
  pages={220-37}
}
Mycobacterium avium subspecies paratuberculosis (MAP) is a significant concern to the American and European dairy industries and possibly to human health. MAP possesses the rare ability to survive and replicate in infected macrophages, cells that are typically able to destroy pathogens. Little is known about what changes occur in MAP-infected macrophages that prevent phagosome maturation and lead to intracellular survival of the bacteria. In this study, a bovine immunologically specific cDNA… CONTINUE READING

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