A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

@article{Gateva2009ALR,
  title={A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus},
  author={Vesela Gateva and Johanna K. Sandling and Geoff Hom and Kimberly W E Taylor and Sharon A. Chung and Xin Sun and Ward Ortmann and Roman Kosoy and Ricardo C Ferreira and Gunnel Nordmark and Iva Gunnarsson and Elisabet Svenungsson and Leonid Padyukov and Gunnar K Sturfelt and Andreas J{\"o}nsen and Anders A. Bengtsson and Solbritt Rantap{\"a}{\"a}-Dahlqvist and Emily C. Baechler and Elizabeth E. Brown and Graciela S Alarc{\'o}n and Jeffrey C. Edberg and Rosalind Ramsey-Goldman and Gerald Mcgwin and John D Reveille and Luis M Vil{\'a} and Robert Kimberly and Susan Manzi and Michelle Petri and Annette T. Lee and Peter K. Gregersen and Michael F. Seldin and Lars R{\"o}nnblom and Lindsey A. Criswell and Ann-Christine Syv{\"a}nen and Timothy W. Behrens and Robert R. Graham},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={1228-1233}
}
Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P < 5 × 10−8): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20… CONTINUE READING