A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.

@article{Wills2009ALI,
  title={A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.},
  author={A-M Wills and Stephen Cronin and Agnieszka Slowik and Dalia Kasperavi{\vc}iūtė and Michael A van Es and Julia M. Morahan and Paul N. Valdmanis and Vincent Meininger and Judith Melki and Christopher E Shaw and Guy A Rouleau and Elizabeth M. C. Fisher and Pamela J Shaw and Karen E. Morrison and Roger Pamphlett and Leonard H van den Berg and Denise A. Figlewicz and Peter Munch Andersen and Ammar Al-Chalabi and Orla Hardiman and Shaun Purcell and John E Landers and Robert H. Brown},
  journal={Neurology},
  year={2009},
  volume={73 1},
  pages={
          16-24
        }
}
BACKGROUND Six candidate gene studies report a genetic association of DNA variants within the paraoxonase locus with sporadic amyotrophic lateral sclerosis (ALS). However, several other large studies, including five genome-wide association studies, have not duplicated this finding. METHODS We conducted a meta-analysis of 10 published studies and one unpublished study of the paraoxonase locus, encompassing 4,037 ALS cases and 4,609 controls, including genome-wide association data from 2,018… CONTINUE READING

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