A large-scale RNAi screen in human cells identifies new components of the p53 pathway

@article{Berns2004ALR,
  title={A large-scale RNAi screen in human cells identifies new components of the p53 pathway},
  author={Katrien Berns and E. Marielle Hijmans and Jasper Mullenders and Thijn R Brummelkamp and Arno Velds and Mike Heimerikx and Ron M. Kerkhoven and Mandy Madiredjo and Wouter Nijkamp and Britta Weigelt and Reuven Agami and Wei Ge and Guy Cavet and Peter S. Linsley and Roderick Leonardus Beijersbergen and Ren{\'e} Bernards},
  journal={Nature},
  year={2004},
  volume={428},
  pages={431-437}
}
RNA interference (RNAi) is a powerful new tool with which to perform loss-of-function genetic screens in lower organisms and can greatly facilitate the identification of components of cellular signalling pathways. In mammalian cells, such screens have been hampered by a lack of suitable tools that can be used on a large scale. We and others have recently developed expression vectors to direct the synthesis of short hairpin RNAs (shRNAs) that act as short interfering RNA (siRNA)-like molecules… CONTINUE READING
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