A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis

  title={A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis},
  author={François Dragon and Jennifer E G Gallagher and Patricia A. Compagnone-Post and Brianna M. Mitchell and Kara A. Porwancher and Karen A. Wehner and Steven Wormsley and Robert E. Settlage and Jeffrey Shabanowitz and Yvonne N. Osheim and A. L. Beyer and Donald F. Hunt and S J Baserga},
Although the U3 small nucleolar RNA (snoRNA), a member of the box C/D class of snoRNAs, was identified with the spliceosomal small nuclear RNAs (snRNAs) over 30 years ago, its function and its associated protein components have remained more elusive. The U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA in all organisms where it has been tested. Biochemical and genetic analyses suggest that U3–pre-rRNA base-pairing interactions mediate… CONTINUE READING
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