A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype.

@article{Rueda2009ALM,
  title={A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype.},
  author={B. Bryan Rueda and Carmen Pilar Sime{\'o}n and Roger Hesselstrand and Ariane Herrick and Jane Worthington and Norb{\'e}rto Ortego-Centeno and Gabriela Riemekasten and Vicente Fonollosa and Madelon C. Vonk and Frank H. J. van den Hoogen and Julio S{\'a}nchez-Rom{\'a}n and M A Aguirre-Zamorano and Rosa Garc{\'i}a-Portales and Anna Pros and Mar{\'i}a Teresa Camps and Miguel A Gonz{\'a}lez-Gay and Mar{\'i}a-Francisca Gonz{\'a}lez-Escribano and Marieke J. H. Coenen and Nathalie F. Lambert and J. Lee Nelson and Timothy R. D. J. Radstake and Javier Mart{\'i}n},
  journal={Annals of the rheumatic diseases},
  year={2009},
  volume={68 10},
  pages={
          1618-20
        }
}
OBJECTIVE To conduct a replication study to investigate whether the -945 CTGF genetic variant is associated with systemic sclerosis (SSc) susceptibility or specific SSc phenotype. METHODS The study population comprised 1180 patients with SSc and 1784 healthy controls from seven independent case-control sets of European ancestry (Spanish, French, Dutch, German, British, Swedish and North American). The -945 CTGF genetic variant was genotyped using a Taqman 5' allelic discrimination assay… CONTINUE READING

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