A large family of bacterial activator proteins.

  title={A large family of bacterial activator proteins.},
  author={Steven Henikoff and George W. Haughn and Joseph M. Calvo and James C. Wallace},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 18},
  • S. Henikoff, G. Haughn, J. Wallace
  • Published 1 September 1988
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
At least nine different bacterial proteins belong to the LysR family. The gene sequence for one of these proteins is presented here. Six others (Escherichia coli LysR, IlvY, CysB; Salmonella typhimurium MetR; Rhizobium NodD; and Enterobacter cloacae AmpR) are known to activate other genes. Based on sequence alignments, each member of this family is predicted to have a helix-turn-helix DNA binding motif near its amino terminus. The combined evidence indicates that all nine proteins are related… 

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coli araC regulatory protein ( 35 ) ; ATC , E . coli aspartate transcarbamylase catalytic subunit ( 36 ) ; HRP , horseradish peroxidase ( 37 ) ; Blac , 3 - lactamase from Tn 3 ( 38 )