A large degree of functional diversity exists among helper T cells specific for the same antigenic site of influenza hemagglutinin.

@article{Haberman1990ALD,
  title={A large degree of functional diversity exists among helper T cells specific for the same antigenic site of influenza hemagglutinin.},
  author={Ann M. Haberman and Christopher Moller and D McCreedy and W. Gerhard},
  journal={Journal of immunology},
  year={1990},
  volume={145 9},
  pages={3087-94}
}
The site-1 determinant of the hemagglutinin molecule of influenza virus (A/PR/8/34) is one of several immunodominant sites in the BALB/c Th cell response to Ha. A synthetic peptide comprising this T cell site (HA110-120), a panel of analogs containing single substitutions in this determinant, and homologs truncated at the amino- or carboxyl-terminal were used to examine the fine specificities of 15 T cells specific for site-1 in the context of I-Ed. The results indicate that every residue… CONTINUE READING