A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N.

@article{Fernandes2004ALA,
  title={A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N.},
  author={S Fernandes and Silvia Paracchini and Lukas H Meyer and Giovanna Floridia and Chris Tyler-Smith and Peter H Vogt},
  journal={American journal of human genetics},
  year={2004},
  volume={74 1},
  pages={180-7}
}
Deletion of the entire AZFc locus on the human Y chromosome leads to male infertility. The functional roles of the individual gene families mapped to AZFc are, however, still poorly understood, since the analysis of the region is complicated by its repeated structure. We have therefore used single-nucleotide variants (SNVs) across approximately 3 Mb of the AZFc sequence to identify 17 AZFc haplotypes and have examined them for deletion of individual AZFc gene copies. We found five individuals… CONTINUE READING
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