A laminin-2, dystroglycan, utrophin axis is required for compartmentalization and elongation of myelin segments.

Abstract

Animal and plant cells compartmentalize to perform morphogenetic functions. Compartmentalization of myelin-forming Schwann cells may favor elongation of myelin segments to the size required for efficient conduction of nerve impulses. Compartments in myelinated fibers were described by Ramón y Cajal and depend on periaxin, mutated in the hereditary… (More)
DOI: 10.1523/JNEUROSCI.5672-08.2009

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