A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer

@inproceedings{PrtegaGomes2013ALS,
  title={A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer},
  author={Nelma P{\'e}rtega-Gomes and Jos{\'e} R{\'a}mon Vizcaino and Jan Attig and Sarah Jurmeister and Carlos Frederico Costa Lopes and F{\'a}tima Baltazar},
  booktitle={BMC Cancer},
  year={2013}
}
In a malignant tumour, cancer cells are embedded in stromal cells, namely cancer-associated fibroblasts (CAFs). These CAFs are now accepted as important players in cancer dynamics, being involved in tumour growth and progression. Although there are various reports on the interaction between tumour and stromal cells, the clinico-pathological significance of this cross-talk is still largely unknown. In this study, we aimed to characterise the expression of key metabolic proteins involved in… CONTINUE READING

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