A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum.

@article{Marchetti2015ALA,
  title={A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum.},
  author={Rosa V. Marchetti and Adele M Lehane and Sarah H Shafik and Markus Winterberg and Rowena Elizabeth Martin and Kiaran Kirk},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={
          6721
        }
}
The intraerythrocytic malaria parasite relies primarily on glycolysis to fuel its rapid growth and reproduction. The major byproduct of this metabolism, lactic acid, is extruded into the external medium. In this study, we show that the human malaria parasite Plasmodium falciparum expresses at its surface a member of the microbial formate-nitrite transporter family (PfFNT), which, when expressed in Xenopus laevis oocytes, transports both formate and lactate. The transport characteristics of… CONTINUE READING
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