A lack of SUMO conjugation affects cNLS-dependent nuclear protein import in yeast.

@article{Stade2002ALO,
  title={A lack of SUMO conjugation affects cNLS-dependent nuclear protein import in yeast.},
  author={K. Stade and Frank Vogel and Ingrid Schwienhorst and Birgit Meusser and Corinna Volkwein and Brigitte Nentwig and R. J{\"u}rgen Dohmen and Thomas M. Sommer},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 51},
  pages={49554-61}
}
Yeast SUMO (Smt3) and its mammalian ortholog SUMO-1 are ubiquitin-like proteins that can reversibly be conjugated to other proteins. Among the substrates for SUMO modification in vertebrates are RanGAP1 and RanBP2/Nup358, two proteins previously implicated in nucleocytoplasmic transport. Sumoylated RanGAP1 binds to the nuclear pore complex via RanBP2/Nup358, a giant nucleoporin, which was recently reported to act as a SUMO E3 ligase on some nuclear substrates. However, no direct evidence for a… CONTINUE READING
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