A labile transcriptional repressor modulates endotoxin tolerance

  title={A labile transcriptional repressor modulates endotoxin tolerance},
  author={K E LaRue and Charles E McCall},
  journal={The Journal of Experimental Medicine},
  pages={2269 - 2275}
Tolerance to bacterial lipopolysaccharide (LPS, endotoxin) is an adaptive cellular process whereby exposure to endotoxin induces a subsequent hyporesponsive state characterized by decreased levels of LPS-induced cytokine mRNA and protein. We demonstrate, in a human promonocytic cell line, THP-1, that endotoxin tolerance is manifested by decreased LPS-induced interleukin 1 beta (IL-1 beta) transcription. Inhibition of protein synthesis reverses the tolerant phenotype by inducing transcription of… CONTINUE READING