A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration.

@article{Fukano2016ALI,
  title={A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration.},
  author={Y. Fukano and N. Okino and S. Furuya and Makoto Ito},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={478 2},
  pages={
          624-30
        }
}
We report the usefulness of an impedance-based label-free whole cell assay to identify new ligands for G protein-coupled receptors (GPCRs) involved in microglial cell migration. Authentic GPCR ligands were subjected to the impedance-based cell assay in order to examine the responses of ligands for MG5 mouse microglial cells. Complement component 5 (C5a), adenosine 5'-diphosphate (ADP), uridine 5'-triphosphate (UTP), lysophosphatidic acid (LPA), and lysophosphatidylserine (LysoPS) were found to… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
Identification of a Novel Human Eicosanoid Receptor Coupled to Gi/o *
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors.
Label-free whole-cell assays: expanding the scope of GPCR screening.
...
1
2
3
4
...