A kojic acid derivative promotes intrinsic apoptotic pathway of hepatocellular carcinoma cells without incurring drug resistance

@article{Oncul2019AKA,
  title={A kojic acid derivative promotes intrinsic apoptotic pathway of hepatocellular carcinoma cells without incurring drug resistance},
  author={S. Oncul and G. Karakaya and Mutlu Dilsiz Aytemir and A. Ercan},
  journal={Chemical Biology & Drug Design},
  year={2019},
  volume={94},
  pages={2084 - 2093}
}
  • S. Oncul, G. Karakaya, +1 author A. Ercan
  • Published 2019
  • Chemistry, Medicine
  • Chemical Biology & Drug Design
  • Hepatocellular carcinoma is one of the most pervasive cancers with low prognosis, high frequency of recurrence, and metastasis. Studies conducted have focused on extricating novel strategies for successful treatment. Kojic acid and its derivatives are already proven to have depigmenting, anti‐inflammatory, and anti‐neoplastic properties. In the present study, kojic acid and its 10 distinct derivatives were tested on HEPG2 cell line for their possible anti‐cancer effect and seven of them were… CONTINUE READING
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