A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression

@inproceedings{Zeineldin2012AKM,
  title={A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression},
  author={Maged Zeineldin and Jamie Cunningham and William McGuinness and Preston Alltizer and Brett C Cowley and Bryan Blanchat and Wenhao Xu and David M. Pinson and Kristi L Neufeld},
  booktitle={Oncogene},
  year={2012}
}
Mutation of the tumor suppressor adenomatous polyposis coli (APC) is considered an initiating step in the genesis of the vast majority of colorectal cancers. APC inhibits the Wnt-signaling pathway by targeting the proto-oncogene β-catenin for destruction by cytoplasmic proteasomes. In the presence of a Wnt signal, or in the absence of functional APC, β-catenin can serve as a transcription cofactor for genes required for cell proliferation such as cyclin-D1 and c-Myc. In cultured cells, APC… CONTINUE READING

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Nuclear Functions of APC

  • KL Neufeld
  • Adv. Exp. Med Biol
  • 2009
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