A kinetic model of transcription initiation by RNA polymerase.

@article{Xue2008AKM,
  title={A kinetic model of transcription initiation by RNA polymerase.},
  author={Xiaochuan Xue and Fei Liu and Zhong-Can Ou-Yang},
  journal={Journal of molecular biology},
  year={2008},
  volume={378 3},
  pages={
          520-9
        }
}
We establish a sequence-dependent kinetic model for the later stage of transcription initiation by RNA polymerase. We suggest that there are three reaction pathways, the abortive pathway, the scrunching pathway and the escape pathway, competitive with each other at each site during the transcription initiation. Using this three-pathway model, we mainly calculate the maximum sizes of the abortive transcripts, the abortive probabilities and the abortive/productive ratios for different promoters… CONTINUE READING

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