A kinetic-dynamic model to explain the relationship between high potency and slow onset time for neuromuscular blocking drugs

@article{Donati1991AKM,
  title={A kinetic-dynamic model to explain the relationship between high potency and slow onset time for neuromuscular blocking drugs},
  author={F. Marchesi Donati and Claude Meistelman},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1991},
  volume={19},
  pages={537-552}
}
To account for experimental data showing increased onset time with increased potency of neuromuscular blocking drugs, a pharmacokinetic-pharmacodynamic model is presented. It is characterized by a finite concentration of receptors (R)in the effect compartment. Transfer from central to effect compartment is linearly related to concentration gradient. A sigmoid Emax model is used to describe the relationship between receptor occupancy and effect. Plasma concentrations found in the literature are… CONTINUE READING
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