A kinetic analysis of hepatic microsomal activation of parathion and chlorpyrifos in control and phenobarbital-treated rats.

@article{Ma1995AKA,
  title={A kinetic analysis of hepatic microsomal activation of parathion and chlorpyrifos in control and phenobarbital-treated rats.},
  author={Tangeng Ma and Janice Elaine Chambers},
  journal={Journal of biochemical toxicology},
  year={1995},
  volume={10 2},
  pages={63-8}
}
A kinetic analysis of cytochrome P450-mediated desulfuration (activation) or dearylation (detoxication) showed that rat hepatic microsomes have a greater capacity to detoxify and a lower capacity to activate chlorpyrifos compared to parathion. Kinetic curves for the desulfuration of both parathion and chlorpyrifos were biphasic; Kmapps of 0.23 and 71.3 microM were calculated for parathion, and 1.64 and 50.4 microM for chlorpyrifos. While phenobarbital (PB) exposure seemed to generally lower the… CONTINUE READING

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