A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.

@article{Boucher2010AKR,
  title={A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.},
  author={J{\'e}r{\'e}mie Boucher and Yazm{\'i}n Macotela and Olivier Bezy and Marcelo Alves-da-Silva Mori and Kristina M. Kriauciunas and C Ronald Kahn},
  journal={Science signaling},
  year={2010},
  volume={3 151},
  pages={ra87}
}
Insulin and insulin-like growth factor 1 (IGF-1) act as antiapoptotic hormones. We found that, unexpectedly, double-knockout (DKO) cells that lacked both insulin and IGF-1 receptors (IR and IGF1R, respectively) were resistant to apoptosis induced through either the intrinsic or the extrinsic pathway. This resistance to apoptosis was associated with decreased abundance of the proapoptotic protein Bax and increases in abundance of the antiapoptotic proteins Bcl-2, Bcl-xL, XIAP, and Flip. These… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…