A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor

@article{Su2010AKC,
  title={A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor},
  author={Tao Su and David M. Bryant and Fr{\'e}d{\'e}ric Luton and Marcel Verg{\'e}s and Scott M. Ulrich and Kirk C Hansen and Anirban Datta and Dennis J. Eastburn and Alma L. Burlingame and Kevan M. Shokat and Keith E. Mostov},
  journal={Nature Cell Biology},
  year={2010},
  volume={12},
  pages={1143-1153}
}
Polymeric immunoglobulin A (pIgA) transcytosis, mediated by the polymeric immunoglobulin receptor (pIgR), is a central component of mucosal immunity and a model for regulation of polarized epithelial membrane traffic. Binding of pIgA to pIgR stimulates transcytosis in a process requiring Yes, a Src family tyrosine kinase (SFK). We show that Yes directly phosphorylates EGF receptor (EGFR) on liver endosomes. Injection of pIgA into rats induced EGFR phosphorylation. Similarly, in MDCK cells, pIgA… CONTINUE READING
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