A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke.

@article{Oldenburger2014AkinaseAP,
  title={A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke.},
  author={Anouk Oldenburger and Wilfred J Poppinga and Fleur Kos and Harold G. de Bruin and Wolter F Rijks and Irene H Heijink and Wim Timens and Herman Meurs and Harm Maarsingh and Martina Schmidt},
  journal={American journal of physiology. Cell physiology},
  year={2014},
  volume={306 6},
  pages={C585-97}
}
Airway epithelium, which forms the first barrier towards environmental insults, is disturbed by cigarette smoking, a major risk factor for developing chronic obstructive pulmonary disease (COPD). A-kinase anchoring proteins (AKAP) maintain endothelial barrier function and coordinate subcellular localization of protein kinase A (PKA). However, the role of AKAPs in epithelial barrier function is unknown. We studied the role of AKAPs in regulating human bronchial epithelial (Hogg JC, Timens W… CONTINUE READING

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