A-kinase anchoring proteins as the basis for cAMP signaling.

  title={A-kinase anchoring proteins as the basis for cAMP signaling.},
  author={Kimberly L. Dodge-Kafka and Andrea L Bauman and Michael S Kapiloff},
  journal={Handbook of experimental pharmacology},
Common challenges to any cell are the processing of the extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude of diverse biological functions. However, many of these stimuli act via a common signaling pathway, suggesting the cell must somehow discriminate between different stimuli and respond accordingly. Subcellular targeting through the association with adaptor and scaffolding proteins has emerged as a key mechanism by which cells maintain signaling… CONTINUE READING