A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.

@article{Poppinga2014AkinaseAP,
  title={A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.},
  author={Wilfred J Poppinga and Pablo Mu{\~n}oz-Llancao and Christian Gonz{\'a}lez-Billault and Martina Schmidt},
  journal={British journal of pharmacology},
  year={2014},
  volume={171 24},
  pages={
          5603-23
        }
}
The universal second messenger cAMP is generated upon stimulation of Gs protein-coupled receptors, such as the β2 -adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and thereby regulates a plethora of distinct biological responses. The broad activation pattern of PKA and its contribution to several distinct cellular functions lead to the introduction of the concept of compartmentalization of cAMP. A-kinase anchoring… CONTINUE READING
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