A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

@article{Fourcade2009AKR,
  title={A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.},
  author={St{\'e}phane Fourcade and Montserrat Ruiz and Carme Camps and Agatha Schl{\"u}ter and Sander M. Houten and Petra A W Mooyer and Teresa P{\`a}mpols and Georges A. A. Dacremont and Ronald J. A. Wanders and Marisa L Giros and Aurora Pujol},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={296 1},
  pages={E211-21}
}
Peroxisomes are essential organelles exerting key functions in fatty acid metabolism such as the degradation of very long-chain fatty acids (VLCFAs). VLCFAs accumulate in X-adrenoleukodystrophy (X-ALD), a disease caused by deficiency of the Abcd1 peroxisomal transporter. Its closest homologue, Abcd2, exhibits a high degree of functional redundancy on the catabolism of VLCFA, being able to prevent X-ALD-related neurodegeneration in the mouse. In the search for specific roles of Abcd2, we… CONTINUE READING
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