A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

  title={A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.},
  author={St{\'e}phane Fourcade and Montserrat Ruiz and Carme Camps and Agatha Schl{\"u}ter and Sander M. Houten and Petra A W Mooyer and Teresa P{\`a}mpols and Georges A. A. Dacremont and Ronald J. A. Wanders and Marisa L Giros and Aurora Pujol},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={296 1},
Peroxisomes are essential organelles exerting key functions in fatty acid metabolism such as the degradation of very long-chain fatty acids (VLCFAs). VLCFAs accumulate in X-adrenoleukodystrophy (X-ALD), a disease caused by deficiency of the Abcd1 peroxisomal transporter. Its closest homologue, Abcd2, exhibits a high degree of functional redundancy on the catabolism of VLCFA, being able to prevent X-ALD-related neurodegeneration in the mouse. In the search for specific roles of Abcd2, we… CONTINUE READING
41 Citations
67 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 41 extracted citations


Publications referenced by this paper.
Showing 1-10 of 67 references

Similar Papers

Loading similar papers…