A key role for Itk in both IFN gamma and IL-4 production by NKT cells.

@article{AuYeung2007AKR,
  title={A key role for Itk in both IFN gamma and IL-4 production by NKT cells.},
  author={Byron B Au-Yeung and Deborah J Fowell},
  journal={Journal of immunology},
  year={2007},
  volume={179 1},
  pages={111-9}
}
NKT cells rapidly secrete cytokines upon TCR stimulation and thus may modulate the acquired immune response. Recent studies suggest that signaling for development and effector function in NKT cells may differ from conventional T cells. The tyrosine kinase Itk is activated downstream of the TCR, and its absence in CD4(+) T cells results in impaired Th2, but not Th1 responses. In this study, we investigated NKT cell function in the absence of Itk as impaired type 2 responses in vivo could be… CONTINUE READING
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