A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.

@article{Gambus2009AKR,
  title={A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.},
  author={Agnieszka Gambus and Frederick J van Deursen and Dimitrios Polychronopoulos and Magdalena Foltman and Richard Claude Jones and Ricky D. Edmondson and Arturo Calzada and Karim Labib},
  journal={The EMBO journal},
  year={2009},
  volume={28 19},
  pages={
          2992-3004
        }
}
The eukaryotic replisome is a crucial determinant of genome stability, but its structure is still poorly understood. We found previously that many regulatory proteins assemble around the MCM2-7 helicase at yeast replication forks to form the replisome progression complex (RPC), which might link MCM2-7 to other replisome components. Here, we show that the RPC associates with DNA polymerase alpha that primes each Okazaki fragment during lagging strand synthesis. Our data indicate that a complex… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 129 CITATIONS

Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2013
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Bacterial and Eukaryotic Replisome Machines.

  • JSM biochemistry and molecular biology
  • 2016
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 23 Highly Influenced Citations

  • Averaged 14 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

Protein affinity chromatography with purified yeast DNA polymerase alpha detects proteins that bind to DNA polymerase.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…