A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes.

@article{Maxeiner2009AKR,
  title={A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes.},
  author={Joachim H. Maxeiner and Roman Karwot and Kerstin A Sauer and Petra Scholtes and Ildiko Boross and Michael Koslowski and Ozlem T{\"u}reci and Rainer Wiewrodt and Markus F Neurath and Hans Anton Lehr and Susetta Finotto},
  journal={Cancer research},
  year={2009},
  volume={69 7},
  pages={3069-76}
}
The Ca(2+)-regulated calcineurin/nuclear factor of activated T cells (NFAT) cascade controls alternative pathways of T-cell activation and peripheral tolerance. Here, we describe reduction of NFATc2 mRNA expression in the lungs of patients with bronchial adenocarcinoma. In a murine model of bronchoalveolar adenocarcinoma, mice lacking NFATc2 developed more and larger solid tumors than wild-type littermates. The extent of central tumor necrosis was decreased in the tumors in NFATc2((-/-)) mice… CONTINUE READING

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