A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.

@article{Zenker2014AKR,
  title={A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.},
  author={Stefanie Zenker and Julia Panteleev-Ivlev and Stefan Wirtz and Tadamitsu Kishimoto and Maximilian J. Waldner and Olga Ksionda and Victor L. J. Tybulewicz and Markus F Neurath and Imke Atreya},
  journal={Journal of immunology},
  year={2014},
  volume={192 6},
  pages={2830-2836}
}
Macrophages are centrally involved in the pathogenesis of acute inflammatory diseases, peritonitis, endotoxemia, and septic shock. However, the molecular mechanisms controlling such macrophage activation are incompletely understood. In this article, we provide evidence that Vav1, a member of the RhoGEF family, plays a crucial role in macrophage activation and septic endotoxemia. Vav1-deficient mice demonstrated a significantly increased susceptibility for LPS endotoxemia that could be abrogated… CONTINUE READING

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