A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase

@article{Banerjee2008AKI,
  title={A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase},
  author={Tinku Banerjee and James B DuHadaway and Paul M Gaspari and Erika Sutanto-Ward and David H. Munn and Andrew L Mellor and William P Malachowski and George C Prendergast and Alexander J Muller},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={2851-2857}
}
Agents that interfere with tumoral immune tolerance may be useful to prevent or treat cancer. Brassinin is a phytoalexin, a class of natural products derived from plants that includes the widely known compound resveratrol. Brassinin has been demonstrated to have chemopreventive activity in preclinical models but the mechanisms underlying its anticancer properties are unknown. Here, we show that brassinin and a synthetic derivative 5-bromo-brassinin (5-Br-brassinin) are bioavailable inhibitors… CONTINUE READING

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