A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis

@article{Zhao2005AKD,
  title={A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis},
  author={Zhong fu Zhao and Dale J. Lange and Andrei Voustianiouk and Donal MacGrogan and L. W. Ho and Jason Suh and Nelson Humala and Meenakshisundaram Thiyagarajan and Jun Wang and Giulio Maria Pasinetti},
  journal={BMC Neuroscience},
  year={2005},
  volume={7},
  pages={29 - 29}
}
The cause of neuronal death in amyotrophic lateral sclerosis (ALS) is uncertain but mitochondrial dysfunction may play an important role. Ketones promote mitochondrial energy production and membrane stabilization. SOD1-G93A transgenic ALS mice were fed a ketogenic diet (KD) based on known formulations for humans. Motor performance, longevity, and motor neuron counts were measured in treated and disease controls. Because mitochondrial dysfunction plays a central role in neuronal cell death in… CONTINUE READING
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