A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity

@inproceedings{Kumar2015AKS,
  title={A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity},
  author={Vinod Kumar and Jamal-Eddine Bouameur and Janina B{\"a}r and Robert H. Rice and Hue-Tran Hornig-Do and Dennis R. Roop and Nicole Schwarz and Susanne Brodesser and S{\"o}ren Thiering and Rudolf E. Leube and Rudolf Josef Wiesner and Preethi Vijayaraj and Christina B. Brazel and Sandra Heller and Hans Binder and Henry Loeffler-Wirth and Peter Seibel and Thomas Michael Magin},
  booktitle={The Journal of cell biology},
  year={2015}
}
Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth. The mechanisms by which type I and II keratins contribute to these functions remain incompletely understood. Here, we report that mice lacking all type I or type II keratins display severe barrier defects and fragile skin, leading to perinatal mortality with full penetrance. Comparative proteomics of cornified envelopes (CEs) from prenatal… CONTINUE READING
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