A keratin peptide inhibits mannose-binding lectin.

  title={A keratin peptide inhibits mannose-binding lectin.},
  author={Michael C. Montalto and Charles D. Collard and Jon A. Buras and Wende R. Reenstra and Rebecca J. McClaine and David R. Gies and Russell P. Rother and Gregory L Stahl},
  journal={Journal of immunology},
  volume={166 6},
Complement plays a significant role in mediating endothelial injury following oxidative stress. We have previously demonstrated that the lectin complement pathway (LCP), which is initiated by deposition of the mannose-binding lectin (MBL), is largely responsible for activating complement on endothelial cells following periods of oxidative stress. Identifying functional inhibitors that block MBL binding will be useful in characterizing the role of the LCP in disease models. The human cytokeratin… CONTINUE READING
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