A kainate receptor linked to nitric oxide synthesis from arginine.

  title={A kainate receptor linked to nitric oxide synthesis from arginine.},
  author={John Garthwaite and Eric Southam and Mark Anderton},
  journal={Journal of neurochemistry},
  volume={53 6},
In slices of young rat cerebellum, the glutamate analogue kainate induced a large accumulation of cyclic GMP, which was inhibited by non-N-methyl-D-aspartate antagonists. Quisqualate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate evoked only small cyclic GMP responses and inhibited the effect of kainate. When tested in cerebellar cell suspensions, glutamate was also a potent antagonist of the cyclic GMP response to kainate. Superoxide dismutase enhanced the response in the isolated… CONTINUE READING
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