A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure.

@article{Adam2014AJF,
  title={A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure.},
  author={William Robert Adam and Richard C O'Brien},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={2014},
  volume={31 9},
  pages={1032-8}
}
AIM The aim was to justify less restrictive use of metformin in stable chronic renal failure, because a literature review reveals metformin is associated with a significantly lower incidence of cardiovascular events and mortality compared with other hypoglycaemic agents, and metformin-associated lactic acidosis is rare and causation uncertain. Studies on intentional metformin overdose and metformin bioavailability, renal clearance and plasma metformin in renal impairment provide evidence in… CONTINUE READING
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