A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9.

@article{Shirato2009AJ,
  title={A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9.},
  author={Haruki Shirato and Satoko Ogawa and Kuniko Nakajima and Masayo Inagawa and Mizuyo Kojima and Makoto Tachibana and Yoichi Shinkai and Takashi Takeuchi},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 2},
  pages={733-9}
}
Covalent modifications of histone tails have critical roles in regulating gene expression. Previously, we identified the jumonji (jmj, Jarid2) gene, the jmjC domain, and a Jmj family. Recently, many Jmj family proteins have been shown to be histone demethylases, and jmjC is the catalytic domain. However, Jmj does not have histone demethylase activity because the jmjC domain lacks conserved residues for binding to cofactors. Independently of these studies, we previously showed that Jmj binds to… CONTINUE READING

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A Jmj Complex Represses cyclin D1 by H3-K9 Methylation

J. C. Hsieh, J. M. Sisk, +4 authors C. C. Thompson
J. Biol. Chem • 2003

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