A joint model for the dependence between clustered times to tumour progression and deaths: A meta-analysis of chemotherapy in head and neck cancer.

@article{Rondeau2015AJM,
  title={A joint model for the dependence between clustered times to tumour progression and deaths: A meta-analysis of chemotherapy in head and neck cancer.},
  author={Virginie Rondeau and Jean-Pierre Pignon and Stefan Michiels},
  journal={Statistical methods in medical research},
  year={2015},
  volume={24 6},
  pages={711-29}
}
The observation of time to tumour progression (TTP) or progression-free survival (PFS) may be terminated by a terminal event. In this context, deaths may be due to tumour progression, and the time to the major failure event (death) may be correlated with the TTP. The usual assumption of independence between the TTP process and death, required by many commonly used statistical methods, can be violated. Furthermore, although the relationship between TTP and time to death is most relevant to the… CONTINUE READING