A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.

@article{Commichau2015AJO,
  title={A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.},
  author={Fabian M. Commichau and Achim Dickmanns and Jan Gundlach and Ralf Ficner and J{\"o}rg St{\"u}lke},
  journal={Molecular microbiology},
  year={2015},
  volume={97 2},
  pages={189-204}
}
Second messengers are key components of many signal transduction pathways. In addition to cyclic AMP, ppGpp and cyclic di-GMP, many bacteria use also cyclic di-AMP as a second messenger. This molecule is synthesized by distinct classes of diadenylate cyclases and degraded by phosphodiesterases. The control of the intracellular c-di-AMP pool is very important since both a lack of this molecule and its accumulation can inhibit growth of the bacteria. In many firmicutes, c-di-AMP is essential… CONTINUE READING
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Biochemical and structural analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes

  • J. Rosenberg, P. Neumann, J. Arens, K. Gunka, V. Kaever, A Dickmanns
  • J Biol Chem
  • 2015
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